IFNG and neoplasm: However, IFNγR1KD melanoma still retained some degree of IFN-γ signaling, evidenced by significant upregulation of inducible PD-L1 by IFN-γ (Supplementary Fig. 1a, the right panel), preventing us from explicitly assessing how tumor loss of IFN-γ signaling modulates TILs and ICB response.