ENO1 and melanoma: While understandably not all the genes showed significant changes in melanoma, we did observe upregulation of ENO1, FASN, and FKBP4, as well as downregulation of GADD45A in IFNGR1Low SKCMs (Supplementary Fig. 5b); on the other hand, patient melanomas resistant to anti-PD-1 exhibited significant increases of ENO1, FKBP4, ODC1, and VEGFA (Supplementary Fig. 5c).