IFNGR1 and melanoma: However, in human melanomas, attenuated IFN-γ signaling as in IFNGR1low SKCMs and in UVMs (lower IFNGR1 expression than SKCMs) is sufficient to induce appreciable effects on TILs, implying that TILs in human melanomas are more sensitive to the dysregulation of tumor IFN-γ signaling.