In addition, these animals were cycled on and completely off NTBC; this regimen could in theory be altered to involve chronic low doses of the drug, for example, in order to reduce the risk of fibrosis as FAH-positive hepatocytes expand to repopulate the liver, as well as avoid the porphyria-like crises and coagulopathy that untreated FAH deficiency causes in HT1 patients65. This evidence concerns the gene FAH and porphyria.