Mice develop adenomas and HCC through a different set of molecular derangements when compared to humans and pigs; in fact, the pig model of HCC has been shown to develop HCC through a similar set of molecular derangements as seen in most human HCCs, including increased TP53 and KRAS expression, sustained angiogenesis resulting from overexpression of PDGFA and ANGPT2, evasion of apoptosis through overexpression of TWIST1 and other mechanisms, reactivation of TERT for telomere maintenance, and Wnt signaling activation62,63. Here, TWIST1 is linked to hepatocellular carcinoma.