Time-course experiments after ORY-1001 in the ASCL1-positive SCLC cell lines NCI-H1876, CORL47, and NCI-H69 confirmed that ZFP36L1 expression is markedly induced after 7 to 8 days of ORY-1001 treatment (Fig. 4a, b and Supplementary Fig. 5a–c). Here, ASCL1 is linked to small cell lung carcinoma.