ASCL1 and acute myeloid leukemia: Interestingly, ZFP36L1 mRNA expression is only expressed at low levels in 3 cancer types: SCLC; Neuroblastoma, a pediatric neural crest tumor that like SCLC is ASCL1-dependent30; and AML, which like SCLC, is uniquely sensitive to LSD1 inhibitors7–9 (Fig. 3a).