We then asked whether ORY-1001 treatment induces ZFP36L1, REST, YAP1, and WWTR1 mRNA expression across multiple ASCL1-positive SCLC cell lines, which had very low expression of ZFP36L1, REST, YAP1, and WWTR1 at baseline (Supplementary Fig. 2a–f). The gene discussed is REST; the disease is small cell lung carcinoma.