Combined LSD1 and KDM5 inhibition with the small molecular inhibitors ORY-1001 and KDM5-C70, respectively, synergistically blocks ASCL1 and cellular proliferation in some SCLC cell lines, including the NCI-H1876 SCLC cell line where ORY-1001 combined with KDM5-C70 nearly completely represses ASCL1 and cellular proliferation15. Here, ASCL1 is linked to small cell lung carcinoma.