ASCL1 and small cell lung carcinoma: Treatment of CORL47, NCI-H1876, and NCI-H69 SCLC cell lines with SOX2 siRNAs or INSM1 siRNAs potently decreased ASCL1 protein levels compared to the non-targeting siRNA control (Fig. 5n, o) showing that SOX2 or INSM1 loss phenocopies ZFP36L1 re-expression with respect to ASCL1.