Two independent sgRNAs targeting the ZFP36L1 promoter induced ZFP36L1 mRNA expression and protein expression in CORL47 cells (Fig. 5a, b) and decreased protein levels of ASCL1 and SOX2, another lineage-specific transcription factor required for SCLC survival and lineage plasticity in neuroendocrine prostate cancer6,33 (Fig. 5b). The gene discussed is ZFP36L1; the disease is small cell lung carcinoma.