SPP1, which mediates Mφ polarization and lung cancer evasion, was shown to be a specific marker in Mφ of LUSC (Fig. 2b).23 Furthermore, the high expression of MARCO, ALOX5AP and SPP1 were all associated with a poor prognosis in LUSC (Fig. 2e). This evidence concerns the gene SPP1 and lung carcinoma.