GZMK and lung carcinoma: The fractions of CD8+ T cells in two lung cancer subtypes were comparable with that in each other (Fig. 1e), but the Effector cells were enriched in LUAD, and cytotoxic, exhausted, GZMK+ Effector as well as KLRC1+ Effector cells were abundant in LUSC (Fig. 4h and Supplementary Fig. 5e).