By contrast, the FN1-related molecular pairs, including FN1-CD44 (a marker of cancer stem cells) and FN1-(ITGAV + ITGB1), were prompted between SELENOP-Mφ/SPP1-Mφ and FABP4-Mφ/FCN1-Mφ/CD4/CD8 cells in LUAD (Fig. 7b). Here, SPP1 is linked to cancer.