Importantly, by analysing ChIP-seq data for SMC3 and KDM3A in the liver cancer cell line HepG2, we found that the number of KDM3A binding peaks located at TSS regions of ARID3A-associated ES genes was much greater than the number of SMC3 binding peaks (Figs. 4D and S4G). The gene discussed is KDM3A; the disease is liver cancer.