Next, we repeated the analysis but used the five HB tumor signatures and found that Hepatoblast I and II showed significant enrichment for the low-risk rC1 gene set compared to other signatures (p < 2.2e−16, two-sided Wilcoxon rank sum test), and the Neuroendocrine tumor subtype was enriched in the high-risk rC2 gene set (p = 5.37e−3, two-sided Wilcoxon rank sum test, Supplementary Fig. 12f). This evidence concerns the gene CBX8 and neuroendocrine neoplasm.