These distinct MARCOlow TAM interactions include PDGF signaling with cells expressing the DCN-high signature, the adhesion molecule CD44 with cells expressing the Erythroid-like signature, members of the TNF receptor superfamily with cells expressing the Hepatoblast I tumor signature, and plexin proteins (PLXNB2) with cells expressing the Neuroendocrine tumor signature (Supplementary Fig. 14f). Here, PLXNB2 is linked to neuroendocrine neoplasm.