The knockdown of the Magel2 gene exclusively in ARCPOMC neurons innervating the MeA protected against DIO in both male and female mice, consistent with prior studies with PWS mouse models, including mice lacking the Magel2 and Snord116 genes (Bischof et al, 2007; Qi et al, 2016). Here, MAGEL2 is linked to Prader-Willi syndrome.