Mammalian genomes encode more than 100 different DUBs grouped into seven evolutionarily conserved families: the Ub-C-terminal hydrolases (UCHs), Ub-specific proteases (USPs), Machado-Joseph domain (MJD) DUBs, ovarian tumor (OTU) domain DUBs (OTU DUBs), the motif interacting with Ub (MIU)-containing novel DUB family (MINDYs), ZUFSP/ZUP1, and the Jab1/Mov34/Mpr1Pad1 N-Terminal+(MPN+) (JAMM) domain proteases (2). This evidence concerns the gene ZUP1 and ovarian neoplasm.