While this dataset may be considered representative of the general melanoma patient population based on previous reports on average age at melanoma diagnosis,37, 38, 39 as well as the higher incidence rate of melanoma observed in aged males compared to females,40 larger studies with more balanced sex ratio, as well as younger patients, are needed to examine sex- and age-differences on IL-6, HGF, and MCP-2 contribution to clinical response to ICI. Here, IL6 is linked to melanoma.