LRRK2 and Parkinson disease: As one of the most promisingdisease-modifying targets, LRRK2 liesat the nexus of an emerging signaling network of high relevance forunderstanding and developing treatments for PD.35 Although three LRRK2-targeting therapies29,36,37 are already in clinical trials, the exactmechanism by which LRRK2 mutations and their kinase activity contributeto the development of PD is still under investigation.