This is achieved via CFTR and apical Cl-/HCO3- exchangers: downregulated in adenoma (DRA, Slc26a3), putative anion transporter 1 (PAT-1, Slc26a6), and anion exchanger isoform 4 (AE4, Slc4a9). This evidence concerns the gene SLC26A3 and adenoma.