The network analysis and Surflex-Dock results have indicated that some key targets, AChE, MAO-B, GluN2B-NMDAR, A2AR and CB2R, can be influenced by SCT in the probable treatment of AD or PD, and other constituents SCT or similar moieties of close chemical structures, such as egonie, sceletium A4, dihydrojoubertiamine, N-trans-feruloyl-3-methyldopamine, N-methyldihydrojoubertinamine and so on, should be concerned to have potential in affecting on corresponding targets (Fig 12). This evidence concerns the gene ADORA2A and Alzheimer disease.