When we explored previous studies on FAM114A1 to understand its function, particularly under hypoxia, we found that apart from its role in neuronal cell development [13], melanocyte apoptosis [32] and an association with ankylosing spondylitis [33], there was very little known about this gene or its homologue FAM114A2. Here, FAM114A2 is linked to ankylosing spondylitis.