Still, in previous publications it could be demonstrated that pyrexia under BRAF/MEK inhibition is associated with an increase of acute phase proteins such as CRP and procalcitonin, with an increase of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and interleukin-6, a decrease of leukocytes and granulocytes and with aberrations of the coagulation system [11–13, 16, 17]. This evidence concerns the gene IL1B and Fever.