Although CRP and LDH levels remain elevated and leukocyte and thrombocyte counts remain depressed shortly after the onset of pyrexia, the pyrexia score returns to low values immediately after the maximum as no further increase of CRP or LDH and no further decrease of leukocytes and thrombocytes occur in the patient after the onset of pyrexia and discontinuation of BRAF/MEK-inhibition. The gene discussed is BRAF; the disease is Fever.