We compared mice bearing U87ΔEGFR glioma cells treated with saline, bevacizumab at 10 mg/kg, Ad-SGE-REIC at 3.6 × 107 pfu, and Ad-SGE-REIC at 3.6 × 107 pfu and bevacizumab at 10 mg/kg (Fig 4B). Here, DKK3 is linked to central nervous system cancer.