For the upregulated genes in the Ad-SGE-REIC-treated U87ΔEGFR glioma brain tissue compared with the control, 14 significantly enriched pathways were identified, including the Notch Signaling Pathway, IL-2 Signaling Pathway, and TNF-alpha NF-kB Signaling Pathway (Table 1). Here, NFKB1 is linked to central nervous system cancer.