We compared mice bearing U87ΔEGFR glioma cells treated with saline, bevacizumab at 10 mg/kg, Ad-SGE-REIC at 3.6 × 107 pfu, and Ad-SGE-REIC at 3.6 × 107 pfu and bevacizumab at 10 mg/kg (Fig 4B). This evidence concerns the gene DKK3 and glioma.