After searching in DrugBank [16], we retrieved a total of 47 anti-epileptic drugs and 151 targets (S2 Table), of which identified 17 target genes (CACNA1A, CHRNA4,CHRNA7,GABRA1,GABRA2,GABRB2,GABRG2,GRIK1,GRIN1,GRIN2B,KCNQ2,KCNQ3,SCN1A,SCN2A, SCN3A,SCN8A and SCN9A) were overlapped with risk genes of epilepsy. The gene discussed is SCN8A; the disease is epilepsy.