STXBP1 and epilepsy: We performed enrichment analysis of 147 genes from our PPI network on 320 genes from a co-expression network of epilepsy [26] (S3 Table), and there were 22 genes (CACNA1C, CACNB2, CACNB4, CHRNB2, DNM1, EEF1A2, GABRA1, GABRA3, GABRA4, GABRB2, GABRB3, GABRG2, GRIN1, KCNA2, KCNC1, KCNQ3, SCN1A, SCN4B, SCN8A, SOD1, STXBP1, and SV2A) from PPI network were enriched in the co-expression network of epilepsy, and Fisher’s Exact Test demonstrated the enrichment was significant (odds ratio [OR] = 11.80, P = 1.30 ×10 −15).