Moreover, when we compared genes in this PPI network with genes from a co-expression network of epilepsy [26] (S3 Table), we also identified a significant enrichment of genes in our PPI network in the co-expression network of epilepsy, with 22 gene overlapped, interestingly, all the 22 genes were anti-epileptic drug targets, in which 7 genes were also risk genes (GABRA1, GABRB2, GABRG2, GRIN1, KCNQ3, SCN1A, and SCN8A). This evidence concerns the gene GRIN1 and epilepsy.