In this study to overcome the limited breadth of NA immunity, we constructed a single entity of VLP presenting multi-subtype consensus NA proteins (m-cNA) including N1 NA, N2 NA, and influenza B NA, as well as M2e repeat consisted of human, swine, avian influenza A M2e (m-cNA-M2e VLP). This evidence concerns the gene XK and avian influenza.