By 5-ethynyl-2′-deoxyuridine (EdU) labeling 24 hours prior to bone harvest from the mice, it was found that higher percentages of IL20RB-overexpressing tumor cells were active in proliferation, while knockdown of IL20RB suppressed proliferation of tumor cells in bone (Figure 2, F, H, and M). The gene discussed is IL20RB; the disease is neoplasm.