Curiously, while we identify a number of CDK8/19 kinase substrates that are consistent with a previous phospho-proteomic analysis in a CRC cell line (e.g., CHD4, MED12, MED13; ref. 44), the SWI/SNF components that we identified were only found in the context of the normal intestine. Here, CDK8 is linked to colorectal carcinoma.