IGFBP7 and exocrine pancreatic carcinoma: The blockade of CD93 pathway could also decrease intratumorally hypoxemia and improve drugs delivery through vasculatures normalizing and leakage reducing, such as the interaction blocking between CD93 and IGFBP7 with mAb remarkably enhanced the antitumoral responses to gemcitabine or fluorouracil in pancreatic carcinoma bearing mice (Sun et al. 2021b).