The interaction between CD93 and multimerin-2 (MMRN2) delivers integrin-dependent signals to regulate Src activation, fibronectin deposition, endosialin loss and prevent the development of fibrosis in ECM during glioma angiogenesis (Liang et al. 2020; Lugano et al. 2020, 2018). This evidence concerns the gene CD248 and central nervous system cancer.