Among them, 96 were recurrent CRC cases, 404 patients co-exist with other severe diseases or received neoadjuvant treatment (12 with a lung cancer history, 25 with breast cancer history, 17 with a renal cancer history, and 350 received neoadjuvant chemotherapy or radiotherapy), and 85 cases without IHC results of HER2 for unknown reasons. This evidence concerns the gene ERBB2 and breast cancer.