Decreased expression of the p16 gene has been reported in the CLBL-1, GL-1, Nody-1, Ema, and UL-1 canine lymphoma cell lines, and hypermethylation of the p16 gene has also been identified in the CLBL-1, GL-1, and UL-1 cell lines [21,22]. This evidence concerns the gene CDKN2A and lymphoma.