In previous study of canine lymphoma cells, low expression of the p16 gene was reported in the CLBL-1, GL-1, Nody-1, Ema, and UL-1 cell lines, and hypermethylation of the p16 gene was observed in the CLBL-1, GL-1, and UL-1 cell lines [21,22]. The gene discussed is CDKN2A; the disease is lymphoma.