STAT3 and neoplasm: However, circMALAT1 (hsa_circ_0002082) acts as a proto-oncogene or tumor-suppressor gene, and circMALAT1 can inhibit the translation of the tumor-suppressor gene PAX5 and also act as a sponge of miR-6887-3p, activate the JAK/STAT3 signaling pathway and promote the self-renewal of cancer stem cells [42].