CD40LG and dengue disease: For the multivariable analysis, the following clinical parameters providing significant predictive ability for infection severity were selected: age (>17 years), anorexia, hematocrit (>40%), neutrophils (≤51%), atypical lymphocyte (>3%), platelet count (≤97 × 103/μL), PT (>13.1 s), PTT (>28.5 s), albumin (≤2.7 g/dL), AST (>104 U/I), ALT (>141 U/I) and immunopositive assays using anti-dengue IgM and anti-dengue IgG (Table 2).