PLA2G2A and gas gangrene: Additionally, there are reports of isolation of BatroxPLA2, an acidic PLA2 with a high catalytic activity that induced the release of IL-6, PGE2, and LTB4 from murine macrophages in culture [32]; BaPLA2M-I, a Lys-49 homologue that induces edema, local myonecrosis, and IL-6 production in vivo [33]; BaPLA(2)I and BaPLA(2)III, two myotoxins with catalytic activity capable of degranulating mast cells in vitro and causing edema and myonecrosis in vivo [34]; and BaMtx, a Lys-49 myotoxic homologue with therapeutic potential [36].