The molecular cloning of the calcitonin gene-related peptide (CGRP), belonging to the six-member family of the calcitonin petides including calcitonin, adrenomedullin 1 and 2, amylin and CGRP α and β [9,10], together with the discovery of its role in pain modulation [11], in meningeal vasodilation [12] and in sensitization of the trigeminal ganglion [13] raised interest in the pathway of this neurotransmitter as target for migraine treatment and prevention of chronification. Here, CALCA is linked to migraine disorder.