PPARG and obesity due to melanocortin 4 receptor deficiency: Comparing the identified molecular events and AOs to the three AOPs, including (1) AOP72: epigenetic modification of PPARG leading to adipogenesis, (2) AOP149: peptide oxidation leading to hypertension, and (3) AOP226: SSRI (selective serotonin reuptake inhibitor) leading to hypertension, which are related to either obesity or hypertension, showed that some of our identified events matched well to citable AOPs (Figure 3).