As seen above, although not being the structural target, AChE seems to be a target for many pesticides, and due to the primary role of AChE in neuronal physiology, i.e., in terminating neuronal signaling between synapses and transmission, its homeostasis disturbance leads to several diseases, namely those involving memory and neuromotor function, such as Alzheimer’s disease [23] and other disorders involving dementia [24]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.