CXCL1/2 are major neutrophil chemoattractants that transduce signals by binding to the receptor, CXCR2 (56, –, 58), which mediates neutrophil recruitment and migration, as well as inflammation, in acute respiratory distress syndrome and acute lung injury (38, 54, –, 56, 59, 60). The gene discussed is CXCR2; the disease is acute respiratory distress syndrome.