HMGB1 and Sepsis: Sepsis occurs when there is organ damage caused by an uncontrolled host immune response that has been triggered by infection [4] and its pathogenesis, hypercytokinemia, includes interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor, and high mobility group box 1 protein (HMGB-1), which is a major inflammatory cytokine [5].