The miR-500A-5P of CAFS-Exos in BC patients can be transferred from adjacent CAFs to BCCs, and by binding to ubiquitin specific peptidase 28 (USP28), the miR-500A-5P of CAFs-Exos can considerably promote the proliferation and metastasis of breast cancer cells by giving it an aggressive phenotype [59]. This evidence concerns the gene USP28 and breast carcinoma.