T-type CaV3.1 and CaV3.2 have been reported to play critical roles in neurological disorders and diseases like absence epilepsy [36,37,38,39], inflammatory pain [40], etc. As a rising anticancer agent under several clinical trials, DIM has been reported to show synergistic anti-colorectal cancer effect with capsaicin [8,9], which is an analgesic agent for peripheral nerve pain [41]. This evidence concerns the gene CACNA1H and nervous system disorder.