Ex vivo fluorescence imaging (Figure 5B–D) demonstrated that the fluorescence signal in the tumor site from the SL1-RNP group was 2.17-fold stronger than that from the RNP group at 48 h, indicating that the SL1 modification greatly enhances the accumulation of SL1-RNP in GBM. Here, RNPC3 is linked to glioblastoma.