In addition, Fe3O4-ICG@IRM nanoparticles are photothermally responsive and can increase the temperature by near-infrared light irradiation, induce tumor cell necrosis and release tumor antigens, further activate CD8+ cytotoxic T cells, and inhibit regulatory Foxp3+ T cell differentiation, thereby enhancing antitumor immunotherapy for primary and metastatic tumors. Here, CD8A is linked to neoplasm.