Of the four infants with the highest weight at PD7 (normal male infant birthweight is 0.4–0.55 kg [31,32]), two of them (1215218 & 1214217) were from Obese mothers that exhibited very high HOMA-IR values with corresponding metabolic dysregulation: hyperglycemia (fasting glucose > 100 mg/dL [33]), hyperinsulinemia (fasting insulin > 100 μU/mL [34]), and triglyceride levels at concentrations that were consistent with metabolic syndrome (fasting triglyceride > 79.7 mg/dL [35]) (Supplementary Table S7). Here, INS is linked to metabolic syndrome.