Antisense oligonucleotide (ASO)-mediated knock down of ABHD6 in murine liver and white adipose tissue of mice protected them from HFD-induced obesity, hepatic steatosis, and insulin resistance [8], suggesting a role of ABHD6 in the pathogenesis of metabolic syndrome. Here, ABHD6 is linked to obesity due to melanocortin 4 receptor deficiency.