MetS+ had a significantly higher REE (mean ± se: MetS+: 5995 ± 87.3 vs. MetS−: 5760 ± 86.3 kJ/d, p = 0.025) when adjusted for age, gender, fat mass (FM), fat-free mass (FFM), ethnicity, season, 25OHD, insulin sensitivity, and time of data collection. This evidence concerns the gene INS and metabolic syndrome.