MAPK8 and Insulin resistance: Excess lipid intermediates in TG synthesis, Diacylglycerol (DAG), phosphatidic acid and lysophosphatidic acid, cause insulin resistance by activating several serine/threonine kinases including PKC, mTOR, c-Jun N-terminal Kinase 1 (JNK-1) and Ikappa B (IkB) Kinase [25].