However, this result stands in stark contrast to previous results demonstrating significantly increased levels of methylation in a wide variety of (non-TDP-43 specific) models of ALS such as: DNA samples [155,156,157,158], post-mortem tissues [128,148,159], various SOD1 rodent models [160], and in vitro iPSCs [161]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.