Methylated Gb3 isoforms could be intermediary metabolites in the deacylation of Gb3 to generate the corresponding LysoGb3 [68], in fact, methylated intermediary metabolites were also found for galabiosylceramide (Ga2), another glycosphingolipid component of cellular membranes, found accumulated in vascular endothelium, nerves, organs and biological fluids of FD patients [69]. The gene discussed is ETFA; the disease is Fabry disease.