Meanwhile, KEGG enrichment demonstrated that these target DEGs were enriched in carbohydrate and lipid metabolism (AMPK signaling pathway, Insulin signaling pathway, Glycolysis/Gluconeogenesis, Fat digestion and absorption, Glycerophospholipid metabolism), programmed cell death (Ferroptosis and Apoptosis), disease (Vibrio cholerae infection, Type II diabetes mellitus, Epstein-Barr virus infection and Graft-versus-host disease), and cancerization (Proteoglycans in cancer, Endometrial cancer, and Non-small cell lung cancer) (Figure 5D, Table S2). Here, INS is linked to graft versus host disease.