Nonetheless, these findings contradict those of Matsumoto N et al. [24], suggesting that biomarkers transforming growth factor (TGF-1) and bone morphogenic protein-2 (BMP-2) rose significantly with remarkable healing responses when in vivo rats with apical periodontitis were treated with Emdogain (enamel matrix derivative) as compared to Propylene Glycol Alginate (PGA), a marine hydrogel-based polysaccharide. The gene discussed is BMP2; the disease is periapical periodontitis.