The blood biochemical analysis was examined for the severity of the metabolic syndromes as follows (Table 2): for NAFLD and dyslipidemia, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), triglyceride, total cholesterol, and low-/high-density lipoprotein (LDL/HDL) cholesterol; for T2D, glucose, insulin, and blood glycated hemoglobin (HbA1c); for renal dysfunction, blood urea nitrogen (BUN) and creatinine. The gene discussed is INS; the disease is metabolic syndrome.