The 50% inhibitory concentration (IC50) values of heteronemin were 2.4 and 0.8 μM for HT-29 cells (KRAS WT CRC) and 1.2 and 0.4 μM for HCT-116 cells (KRAS MT CRC) at 24 and 72 h, respectively. This evidence concerns the gene KRAS and colorectal carcinoma.