The results show that the phosphorylated and total protein expression levels of PI3K were significantly downregulated in HT-29 cells (KRAS WT CRC) with combination treatment compared to the control for 24 h (Figure 4A), whereas there were unaffected in HCT-116 cells (KRAS MT CRC; Figure 4B). Here, KRAS is linked to colorectal carcinoma.