TIMP3 and coronary artery disorder: In the fixed−effect IVW model, the per log increase in the circulating TIMP3 levels conferred a protective effect on CAD (OR, 0.97; 95% confidence interval (CI), 0.95, 0.98; p = 5.29 × 10−5) and MI (OR, 0.96; 95% CI, 0.95, 0.98; p = 3.85 × 10−5) based on the CARDIoGRAMplusC4D datasets (Figure 2 and Figure 3).