In the present study, we observed that hypertension-enhanced cardiac apoptosis led to high levels of SIRT1 and p-JNK, as well as low levels of PGC-1α in the hearts of untreated hypertensive rats, which might imply that the increase in the SIRT1 level may be a compensatory mechanism in hypertension. This evidence concerns the gene MAPK8 and Hypertension.