PPARG and hypertensive disorder: Compared with other AT1R antagonists, such as Losartan and Olmesartan, Irbesartan (ARB) has a potent and highly selective AT1R blocker that enables it to partially activate peroxisome proliferator-activated receptor gamma (PPAR-γ) agonistic effects, and has been approved worldwide for the treatment of hypertension in animals and humans [13,14,15].