FAS and Hypertension: Consistent with previous studies, we observed that the ARB treatment exhibited significant anti-apoptotic potential, as evidenced by the upregulation of the SIRT1/PGC-1α pro-survival pathway and the downregulation of Fas/FasL-mediated and mitochondria-mediated apoptotic pathways together with a reduction in the percentage of TUNEL-positive cells in hypertension, which might imply that ARB might be a possible therapeutic approach to prevent or suppress hypertension-induced widely dispersed apoptosis in the heart associated with enhancing pro-survival pathways and mitochondrial biogenesis.