SIRT1 and hypertensive disorder: Next, to evaluate the pro-survival effects of the ARB treatment on the cardiac SIRT1/PGC-1α pro-survival pathway in hypertension, the cardiac SIRT1/PGC-1α pro-survival relative protein expression was measured by Western blot methods in the left ventricles excised from the WKY, SHR, and SHR-ARB groups.