PCSK9 and thrombophilia: In line with Camera et al., Dwivedi et al.’s study has demonstrated that the sepsis-induced hypercoagulation state is worsened in PCSK9-overexpressing mice, as shown by increasing the thrombin–antithrombin complex and decreasing plasma protein C levels, suggesting that upregulation of PCSK9 is positively correlated with blood coagulation [32].