LGALS3 and hydrops fetalis: In a study on 247 patients (172 classified as HFpEF, 30 controls without HF, 45 with HFrEF) followed for 1 year, Gal-3 distinguished HFpEF from controls (AUC = 0.819, 95% CI 0.75–0.89) and HFrEF (AUC = 0.863, 95% CI 0.79, 0.93), while sST2 had a lower AUC for predicting HFpEF vs. controls (AUC = 0.584, 95% CI 0.49–0.68) and HFpEF vs. HFrEF (AUC = 0.824, 95% CI 0.73–0.90), revealing that Gal-3 seemed superior to sST2 in distinguishing HFpEF from controls and HFrEF [89].