Moreover, we have also previously shown that sustained administration of desHis1Pro4Glu9-glucagon, or its Lys12 acylated counterpart, can reverse aspects of genetically induced and dietary-induced obesity-related diabetes in obese-diabetic (ob/ob) and high-fat-fed (HFF) mice, respectively (O’Harte et al. 2014). The gene discussed is GCG; the disease is diabetes mellitus.