In 2010, Jensen et al. reported that the CTSK inhibitor odanacatib (ODN) could inhibit bone resorption in patients with breast cancer and bone metastases, indicating the ODN can be used to treat MBD, and CTSK could be used as a novel therapeutic target for treating MBD [118]. The gene discussed is CTSK; the disease is Marchiafava-Bignami disease.